Columbia University in the City of New York · GeneticsInhibitory Neuron Development Lab
Kristin Kay Baldwin · New York, New York
Research Focus
Dr. Kristin Kay Baldwin’s research focuses on understanding how inhibitory interneurons, a crucial type of brain cell, develop and function. These neurons play a key role in regulating brain activity and are linked to various neurological disorders like autism and schizophrenia. Her lab aims to discover the genetic programs that allow these neurons to specialize and connect within brain circuits, ultimately leading to new therapies for brain diseases.
inhibitory interneuronsneuropsychiatric disordersautismschizophrenianeurodegenerationgenetic reprogrammingtranscription factorscell phenotypedisease modeling
Research Aims
5AIM 01Identify genetic programs that dictate interneuron specialization.
AIM 02Produce specific interneuron subpopulations in vitro for research purposes.
AIM 03Test functional characteristics of induced interneurons in vitro and in vivo.
AIM 04Develop assays to evaluate synaptic specificity of synthetic neurons.
AIM 05Explore links between interneuron dysfunction and neuropsychiatric disorders.
Skills the Lab Values
cell culturein vitro assaysdeep phenotypinggene editingRNA sequencingtranscription factor screeningmigration assaysAI-enabled image analysislineage tracing
Output against the department
Publications47bottom 8% of dept.238th of 259
this lab
most publishedleast published
Citations4.2kbottom 22% of dept.203rd of 259
this lab
most citedleast cited
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