University of Pennsylvania · GeneticsWu Lab
Hao Wu · Philadelphia, Pennsylvania
Research Focus
Dr. Hao Wu's lab at the University of Pennsylvania focuses on how genetic variations impact gene regulatory networks and influence cellular behavior. By using advanced techniques like single-cell multi-omics and machine learning, the lab aims to uncover the complex relationships between genomic variants and gene expression across different cell types. This research is particularly important for understanding human diseases and developmental processes, ultimately paving the way for new therapeutic approaches.
gene regulatory networksgenomic variantssingle-cell multi-omicshuman developmentdisease risk
Research Aims
5AIM 01Characterize how genetic variants influence gene expression in different cell types.
AIM 02Develop computational methods for analyzing single-cell multi-omic data.
AIM 03Investigate the role of cis-regulatory elements in cellular phenotypes.
AIM 04Utilize human iPSC lines to study developmental dynamics.
AIM 05Apply perturbation techniques to explore network-level relationships between genetics and phenotypes.
Skills the Lab Values
single-cell RNA sequencingATAC-seqhigh-throughput genetic perturbationmachine learningdata integrationcell differentiationstem cell culturecomputational modelingepigenetic editing
Output against the department
Publications573top 10% of dept.26th of 259
this lab
most publishedleast published
Citations53ktop 11% of dept.28th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.