University of North Texas · EngineeringCardiovascular Drug Safety Lab
Huaxiao Yang · Denton, Texas
Research Focus
Dr. Huaxiao Yang's lab at the University of North Texas focuses on improving cancer drug safety by studying the heart's responses to specific cancer treatments. They are developing an innovative system that uses human heart-like tissue models and artificial intelligence to predict adverse heart effects caused by cancer drugs, particularly tyrosine kinase inhibitors. This research aims to enhance our understanding of drug-induced cardiotoxicity and aims to make drug testing more reliable and efficient.
tyrosine kinase inhibitorscardiotoxicityorganoid modelsartificial intelligencedrug safetyhuman cardiovascular systempharmaceutical developmentpreclinical evaluation
Research Aims
3AIM 01Establish an organoid-AI system to assess the cardiotoxicity of tyrosine kinase inhibitors.
AIM 02Investigate how tyrosine kinase inhibitors affect cardiovascular structure in organoids.
AIM 03Phenotype cardiovascular dysfunction in organoid models caused by cancer drugs.
Skills the Lab Values
stem cell cultureorganoid generationAI data analysiscardiovascular function assessmentfluorescence microscopycell viability assaysimmunostaining techniquesdata visualizationsoftware programming (Python)
Output against the department
Publications85bottom 18% of dept.228th of 278
this lab
most publishedleast published
Citations2.2kbottom 16% of dept.234th of 278
this lab
most citedleast cited
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