Washington University in St Louis · NeuroscienceParkinson's Cognitive Research Lab
Paul T Kotzbauer · Saint Louis, Missouri
Research Focus
Dr. Paul T. Kotzbauer's lab focuses on understanding how protein aggregation impacts cognitive decline in Parkinson's disease. They investigate how the buildup of certain proteins in the brain, like alpha-synuclein, contributes to dementia and other cognitive deficits in patients with Parkinson's. By analyzing brain tissue from autopsy samples, the lab aims to uncover the relationship between these protein accumulations, neuronal degeneration, and cognitive functioning in patients.
Parkinson's diseaseprotein aggregationcognitive impairmentneurotransmittersLewy body dementiaalpha-synucleintau proteinsneural degeneration
Research Aims
4AIM 01Analyze postmortem brain tissue from Parkinson's disease patients to quantify alpha-synuclein and tau protein accumulation.
AIM 02Examine the relationship between protein accumulation and neuronal degeneration in various brain regions.
AIM 03Investigate how these pathological changes relate to cognitive deficits in attention, memory, and other functions.
AIM 04Identify therapeutic targets and biomarkers relevant to cognitive impairment in Parkinson's disease.
Skills the Lab Values
immunohistochemistrypostmortem tissue analysisfrozen brain tissue samplingcognitive assessment methodslongitudinal study designdata analysisEnzyme-Linked Immunosorbent Assay (ELISA)High Pressure Liquid Chromatography (HPLC)
Output against the department
Publications97bottom 32% of dept.454th of 671
this lab
most publishedleast published
Citations7.7ktop 48% of dept.321st of 671
this lab
most citedleast cited
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