University of California-San Diego · Biomedical EngineeringB-Cell Immunotherapy Research Lab
Andrew B. Sharabi · La Jolla, California
Research Focus
Dr. Andrew B. Sharabi's lab at UC San Diego focuses on understanding how B-cells can contribute to successful outcomes in immunotherapy for patients with head and neck cancer. They explore the mechanisms that allow certain patients to achieve durable complete responses to cancer treatment, potentially leading to new therapies that enhance the immune system's ability to fight tumors. The lab's research aims to improve our understanding of cancer immunotherapy and how B-cell activity can be harnessed to develop better treatments for patients.
immunotherapyB-cell activityhead and neck cancertumor controlcheckpoint blockade
Research Aims
3AIM 01Investigate the impact of checkpoint blockade immunotherapy on B-cell activation.
AIM 02Identify B-cell subtypes that contribute to anti-tumor immunity.
AIM 03Characterize antibody repertoires in patients with durable responses to immunotherapy.
Skills the Lab Values
B-cell cultureflow cytometryimmunophenotypinganimal modelsantibody profilingcellular assaysPCRWestern blotdata analysis with R
Output against the department
Publications247top 40% of dept.238th of 595
this lab
most publishedleast published
Citations6.6ktop 50% of dept.298th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.