University of Rochester · PharmacologyXia Synapse Lab
Houhui Xia · Rochester, New York
Research Focus
Dr. Houhui Xia's lab at the University of Rochester studies how different forms of protein phosphatase 1 (PP1) affect brain functions related to memory and learning. They use special mouse models to explore how these proteins impact synapses—the connections between neurons—by examining their roles in processes like synaptic transmission and long-term potentiation. Their findings could lead to new treatment strategies for neurodegenerative diseases.
protein phosphatasesynaptic transmissionmemory formationneurodegenerative diseaseslong-term potentiation
Research Aims
3AIM 01Investigate how PP1 and MYPT1 inhibit spine maturation and synaptic transmission.
AIM 02Explore the role of PP1 and Nrb in promoting spine maturation and synaptic transmission.
AIM 03Determine the distinct effects of PP1 isoforms on long-term potentiation and memory formation.
Skills the Lab Values
conditional knockout mouse modelsWestern blotPCRprotein purificationcell culture
Output against the department
Publications54bottom 8% of dept.424th of 462
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.256th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.