Wayne State University · PhysiologyDiabetes Technology and Innovation Lab
Ulrike Klueh · Detroit, Michigan
Research Focus
Dr. Ulrike Klueh's lab focuses on developing innovative technologies to improve insulin delivery systems for diabetes management. They aim to enhance the longevity and effectiveness of insulin infusion pumps by addressing the inflammatory reactions caused by preservatives in insulin. Their research combines biomedical engineering and physiology to create solutions that alleviate tissue damage from subcutaneous insulin administration, thus aiming to improve the quality of life for diabetes patients.
diabetes technologyinsulin infusion pumpsinflammationdrug deliverycytotoxicitytissue integritydiabetic complicationsfiltration systemsbiomedical engineeringmast cell activation
Research Aims
3AIM 01Investigate how insulin preservatives activate mast cells and contribute to tissue inflammation.
AIM 02Develop a platform to reduce cytotoxic preservatives in insulin formulations.
AIM 03Evaluate long-term tissue integrity during insulin infusion therapies in pre-clinical models.
Skills the Lab Values
mouse modelsin vivo experimentationcell culturebiochemical assaysflow cytometrymolecular biology techniquestissue histologydrug formulationspectrophotometrytransgenic models
Output against the department
Publications63bottom 12% of dept.253rd of 286
this lab
most publishedleast published
Citations1.7kbottom 9% of dept.259th of 286
this lab
most citedleast cited
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