University of California-Los Angeles · GeneticsObesity and Cardiovascular Health Unit
Karen Reue · Los Angeles, California
Research Focus
Dr. Karen Reue's lab at UCLA focuses on understanding how genetic factors, particularly on the X chromosome, influence obesity and related cardiovascular disease risks in women. They explore how the Kdm5c gene affects fat storage and energy balance, especially during menopause, aiming to uncover how sex differences play a role in these health issues. Ultimately, this research seeks to inform better prevention strategies for obesity and cardiovascular disease in both genders.
obesitycardiovascular diseaseKdm5cepigeneticsX chromosomeadipose tissuemenopausesex differences
Research Aims
3AIM 01Investigate the role of Kdm5c gene dosage in weight gain during hypogonadal states.
AIM 02Map histone modifications and gene expression profiles in adipose tissue influenced by sex hormones and Kdm5c dosage.
AIM 03Examine the impact of sex and hormonal status on histone landscapes in human adipose tissue.
Skills the Lab Values
gene expression analysishistone modification mappingRNA sequencingmouse modelsEPIC-seqCUT&RUNcell culturesingle-cell RNA sequencingbioinformatics
Output against the department
Publications335top 25% of dept.64th of 259
this lab
most publishedleast published
Citations24ktop 23% of dept.60th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.