California Institute of Technology · EngineeringShapiro Lab
Mikhail Shapiro · Pasadena, California
Research Focus
Mikhail Shapiro's lab at Caltech focuses on developing cutting-edge techniques to control cellular behavior using ultrasound. This novel approach, called sonogenetics, aims to overcome limitations of traditional optical techniques by allowing researchers to manipulate cells deep within living tissues. The research has potential applications in neuroscience and cell therapy, helping advance our understanding of biological processes and improving treatment methods.
ultrasoundsonogeneticscellular controlimmunotherapyneurosciencemechanosensitive receptorsacoustic biosensorscell-based therapies
Research Aims
5AIM 01Develop techniques to control cellular functions using ultrasound.
AIM 02Create genetically encoded acoustic antennae to enable deep tissue manipulation.
AIM 03Investigate the applications of sonogenetics in neuroscience.
AIM 04Enhance cell-based therapy methods using ultrasound for targeted control.
AIM 05Establish frameworks for studying cellular processes in vivo using ultrasound.
Skills the Lab Values
ultrasound imagingcell culturegene editingmechanical force applicationimmunological assaysanimal modelsoptogenetics principlesfluorescence microscopyacoustic biosensor development
Output against the department
Publications204top 46% of dept.128th of 278
this lab
most publishedleast published
Citations9.0ktop 41% of dept.113th of 278
this lab
most citedleast cited
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