Duke University · BiologySoderling Lab
Scott H Soderling · Durham, North Carolina
Research Focus
Dr. Scott H. Soderling's lab at Duke University investigates how specific proteins called kinases regulate neuronal function and contribute to brain disorders. The lab employs advanced techniques like AI algorithms and CRISPR to explore the molecular mechanics underlying neurodegenerative diseases, such as Parkinson's, and developmental disorders like Autism Spectrum Disorder. They aim to deepen our understanding of these conditions and identify potential therapeutic strategies.
kinase signalingneurodegenerative disordersParkinson's diseaseAutism Spectrum DisorderproteomicsCRISPRAI/ML algorithmsneuron physiologysynaptic pathologymolecular mechanisms
Research Aims
5AIM 01Investigate how dysregulation of kinase signaling contributes to neurodegenerative diseases.
AIM 02Explore the impact of specific mutations on neuronal survival and function.
AIM 03Identify common molecular mechanisms among genes linked to Autism Spectrum Disorders.
AIM 04Utilize proteomic and genomic techniques to understand synaptic pathology.
AIM 05Develop novel therapeutic strategies targeting kinase interactions to improve brain health.
Skills the Lab Values
CRISPR/Cas technologyproteomicssingle-cell RNA sequencingin vivo modelsmolecular cloningcell culturedata analysis using AIbioinformaticsWestern blottingneuron imaging
Output against the department
Publications98bottom 34% of dept.676th of 1,033
this lab
most publishedleast published
Citations7.8ktop 47% of dept.490th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.