University of California-San Francisco · BiochemistryHolton Structural Lab
James M Holton · San Francisco, California
Research Focus
James Holton's lab focuses on structural biology, particularly understanding how the structures of macromolecules relate to their functions. They develop new methods and tools for accurate molecular modeling and data collection to bridge the gap between predicted and real structures of biological molecules. By improving the resolution and accuracy of imaging techniques, the lab aims to unlock deeper insights into essential biological processes and drug design.
structural biologymacromolecular modelingdrug designcrystallographyCryoEMbiological functionsimulationdata collection
Research Aims
5AIM 01Develop new tools for structural analysis in biology.
AIM 02Enhance the accuracy of molecular modeling techniques.
AIM 03Investigate structure-function relationships in enzymes.
AIM 04Create damage-free imaging methods for macromolecules.
AIM 05Integrate multiple sources of structural data for improved insights.
Skills the Lab Values
3D structural modelingmacromolecular crystallographydata collection techniquesCryo-electron microscopyradiation damage mitigationcomputer simulationsanalysis of structural dataparameter fittingX-ray beam optimization
Output against the department
Publications177top 48% of dept.192nd of 402
this lab
most publishedleast published
Citations14ktop 33% of dept.133rd of 402
this lab
most citedleast cited
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