Indiana University-Purdue University-Indianapolis · BiologyThe Trisomy Lab
Randall J Roper · Indianapolis, Indiana
Research Focus
The lab led by Dr. Randall J. Roper focuses on understanding the genetic factors that influence Down syndrome (DS) traits. They specifically look at how different genes, including those not directly associated with DS, can affect physical and cognitive characteristics in individuals with Down syndrome. Their work involves creating advanced mouse models to better represent the variety of symptoms seen in humans with trisomy 21, particularly investigating how factors like sex and skeletal development might modify these traits.
Down syndromegenetic modifiersmouse modelsskeletal developmentcognitive traitssex differencesphenotype variabilitygene-phenotype relationshipsneurobehavioral traitsQTL analysis
Research Aims
3AIM 01Create diverse DS mouse model lines to study gene contributions to Down syndrome traits.
AIM 02Identify non-triplicated modifier genes affecting DS skeletal phenotypes.
AIM 03Investigate the impact of skeletal improvements on cognitive functions in DS models.
Skills the Lab Values
mouse modelsgenetic analysisphenotypingmechanical stimulation techniquesQTL mappingmolecular cloninghistologystatistical data interpretationbehavioral assaysbone health assessment
Output against the department
Publications124bottom 45% of dept.569th of 1,033
this lab
most publishedleast published
Citations3.4kbottom 25% of dept.771st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.