UTHThe University of Texas Health Science Center at Houston · Neuroscience
Marrelli Lab
Sean P Marrelli · Houston, Texas
Research Focus
Dr. Sean Marrelli's lab at the University of Texas Health Science Center focuses on understanding how certain proteins affect blood flow in the brain and their roles in diseases like Alzheimer's. They are investigating how von Willebrand factor (VWF) contributes to blood vessel problems in amyloidosis and how the Piezo1 ion channel helps regulate cerebral blood flow. The goal is to identify mechanisms that could help treat or prevent neurodegenerative diseases by improving blood circulation in the brain.
Alzheimer's DiseaseCerebrovascular DysfunctionAmyloidosisVon Willebrand FactorPiezo1 Ion Channel
Research Aims
3AIM 01Investigate how VWF modifies smooth muscle function in blood vessels affected by amyloidosis.
AIM 02Examine the impact of intramural VWF on cerebrovascular function and amyloid development.
AIM 03Assess if reducing VWF in mouse models can preserve brain blood flow and function.
Skills the Lab Values
Cell CultureMouse ModelsWestern BlotRNA SequencingLaser Speckle Imaging
Output against the department
Publications166top 45% of dept.300th of 671
this lab
most publishedleast published
Citations2.8kbottom 19% of dept.546th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.