Florida International University · ChemistryEpigenetic Therapeutics Lab
Yuan Liu · Miami, Florida
Research Focus
Dr. Yuan Liu's lab focuses on using advanced genetic techniques to explore potential treatments for Friedreich's ataxia, a hereditary disease caused by repeated sequences in a specific gene. The research aims to manipulate epigenetic factors to contract these repeated sequences and restore the gene's function, possibly leading to new therapies for this and related disorders. The lab incorporates innovative tools such as CRISPR technology and AI-assisted simulations to understand and improve DNA repair mechanisms.
Friedreich's ataxiaCRISPRgene therapyhistone demethylationDNA repairepigeneticsbioengineeringnanoparticlesmachine learningsingle-cell analysis
Research Aims
5AIM 01Investigate the role of histone demethylation in contracting GAA repeats associated with Friedreich's ataxia.
AIM 02Develop CRISPR/dCas9-based methods for targeted gene activation and epigenetic modification.
AIM 03Utilize human vault nanoparticles to deliver gene-editing tools effectively to target cells.
AIM 04Analyze the effects of demethylation on gene expression and cellular function in model systems.
AIM 05Employ AI tools to enhance understanding of histone interactions and gene targeting strategies.
Skills the Lab Values
CRISPR gene editinghistone modification analysisDNA base excision repair assayscell culturemolecular dynamics simulationsnanoparticle formulationtransgenic mouse modelssingle-cell sequencingdata analysis with Pythonbiochemical assays
Output against the department
Publications874top 5% of dept.11th of 216
this lab
most publishedleast published
Citations65ktop 4% of dept.8th of 216
this lab
most citedleast cited
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