Loyola University Chicago · PhysiologyAtrial Function and Disease Group
David Y Barefield · Chicago, Illinois
Research Focus
David Y. Barefield's lab focuses on understanding the function of the heart's atrial region, which plays a vital role in overall cardiac health. They are investigating how specific proteins that are unique to the atria impact heart function, particularly in conditions like cardiomyopathy. By modeling genetic mutations associated with heart disease in lab-grown cells, they aim to reveal mechanisms underlying atrial dysfunction and its contribution to broader heart problems.
cardiomyopathyheart failurecardiac functionprotein regulationcardiac myocytes
Research Aims
5AIM 01Investigate the role of atrial-specific proteins in heart function.
AIM 02Model genetic mutations in stem cell-derived cardiomyocytes.
AIM 03Assess how protein binding affects cardiac contractility.
AIM 04Explore the mechanisms of atrial myopathy and its effects on heart health.
AIM 05Examine the relationship between protein stoichiometry and heart disease.
Skills the Lab Values
cell culturegenetic mutation modelingcontractility assessmentinduced pluripotent stem cellsbiochemical assays
Output against the department
Publications85bottom 21% of dept.227th of 286
this lab
most publishedleast published
Citations2.0kbottom 12% of dept.251st of 286
this lab
most citedleast cited
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