University of Florida · NeuroscienceAbisambra Lab
Jose Francisco Abisambra · Gainesville, Florida
Research Focus
Dr. Jose Francisco Abisambra's lab studies how a protein called tau affects memory and contributes to frontotemporal dementia (FTD). They investigate how abnormal tau interacts with cellular machinery that translates genetic information into proteins, which is crucial for brain function. By understanding this link, the lab aims to uncover potential therapeutic targets to help those affected by memory impairments related to dementias.
tauopathiesfrontotemporal dementiaprotein synthesisribosomal dysfunctionmemory impairment
Research Aims
5AIM 01Investigate how mutant tau affects protein translation
AIM 02Determine the interaction of tau with ribosomal complexes
AIM 03Assess the impact of ribosomal dysfunction on memory in FTD models
AIM 04Develop novel screening tools for ribosomal function modulators
AIM 05Explore therapeutic strategies for addressing tau-mediated neurodegeneration
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingbiological assays
Output against the department
Publications104bottom 35% of dept.434th of 671
this lab
most publishedleast published
Citations6.5kbottom 44% of dept.373rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.