Columbia University in the City of New York · NeuroscienceSocial Memory and Circuitry Lab
Steven A Siegelbaum · New York, New York
Research Focus
Dr. Steven Siegelbaum's lab at Columbia University focuses on understanding how the brain processes social memories, specifically through the hippocampus and its CA2 region. The research explores how the brain distinguishes between rewarding and threatening social interactions, which is crucial for social functioning. By using animal models, the lab aims to uncover the neural circuits involved in memory and social behavior, and how alterations in these circuits may be linked to conditions like anxiety and schizophrenia.
social memoryhippocampusCA2 regionsocial anxietyneuropsychiatric disordersfear discriminationodor-reward learningneural circuitschemogeneticsoptogenetics
Research Aims
3AIM 01Investigate how the CA2 hippocampal region mediates social fear discrimination memory.
AIM 02Explore the role of ventral CA1 and CA2 in processing social fear versus non-social fear.
AIM 03Determine how neural activity in CA2 correlates with social memory and learning.
Skills the Lab Values
calcium imagingoptogeneticschemogenetic silencingmouse models2-photon microscopybehavioral assaysneural circuit mappingsocial odor learningdata analysisanimal handling
Output against the department
Publications165top 45% of dept.301st of 671
this lab
most publishedleast published
Citations20ktop 21% of dept.141st of 671
this lab
most citedleast cited
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