Harvard University · BiologyRamanathan Astrocyte Lab
Sharad Ramanathan · Cambridge, Massachusetts
Research Focus
Dr. Sharad Ramanathan's lab at Harvard University focuses on understanding how specific cells in the human brain, called astrocytes, develop and function. They create advanced models of the human brain using stem cells to explore the genetic and environmental factors that influence brain development. Ultimately, this research aims to improve our understanding of various brain diseases and may help develop new treatments.
astrocytescortical developmentstem cellsbrain organoidsgene editing
Research Aims
5AIM 01Investigate the mechanisms of astrocyte generation in the human brain.
AIM 02Develop in vitro models that accurately represent human brain development.
AIM 03Identify signaling pathways involved in astrocytic fate determination.
AIM 04Perform genetic perturbations to uncover brain development mechanisms.
AIM 05Establish a platform for high throughput analysis of brain development.
Skills the Lab Values
cell cultureCRISPRsingle-cell genomicsimmunostaininglive imagingbioengineeringdata analysislineage tracinggenetic perturbationtissue modeling
Output against the department
Publications112bottom 39% of dept.629th of 1,033
this lab
most publishedleast published
Citations6.2kbottom 45% of dept.571st of 1,033
this lab
most citedleast cited
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