Vanderbilt University · BiochemistryThe NeuroSignal Lab
Bruce D Carter · Nashville, Tennessee
Research Focus
Dr. Bruce D. Carter's lab at Vanderbilt University studies how signals affect the development of the nervous system, particularly focusing on the processes that lead to the degeneration of neurons and connections. The lab aims to understand the mechanisms behind neuronal cell death and how they may contribute to neurological disorders such as Alzheimer's disease and autism. By exploring the role of specific receptors and molecular signals, their research seeks to uncover new insights into nervous system development and disease.
neurodevelopmentaxon degenerationneurotrophinp75 neurotrophin receptorcell deathautismAlzheimer's diseasesignaling pathways
Research Aims
3AIM 01Investigate how p75 neurotrophin receptor mediates long-distance regressive signaling during neuronal death and axon degeneration.
AIM 02Examine the process of p75 neurotrophin receptor palmitoylation and its role in regressive signaling.
AIM 03Understand the effects of progressive signaling on regressive processes in neurons.
Skills the Lab Values
PCRcell culturemouse modelsWestern blotimmunohistochemistryRNA sequencingmicroscopyendosomal traffickingprotein purification
Output against the department
Publications89bottom 21% of dept.318th of 402
this lab
most publishedleast published
Citations6.4kbottom 37% of dept.255th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.