Ohio University-Main Campus · BiologyTau Research Laboratory
Daewoo Lee · Athens, Ohio
Research Focus
Dr. Daewoo Lee's lab at Ohio University focuses on understanding Alzheimer's disease through the study of tau proteins, which become abnormal in this condition. The research investigates how tau proteins are released from neurons and how they contribute to the spread of Alzheimer's disease. By using model systems like Drosophila and human cell lines, the lab aims to uncover the molecular mechanisms behind tau release and propagation, paving the way for potential new therapies.
Alzheimer's diseasetau proteinsneurodegenerationtau releaseDrosophilahuman cell linestauopathiessynaptic transmission
Research Aims
3AIM 01Investigate how tau proteins are released from neurons during hyperexcitability.
AIM 02Identify new proteins that interact with tau and influence its release.
AIM 03Validate the findings in human neural cell lines that express tau.
Skills the Lab Values
Drosophila geneticscell cultureprotein interaction assaysmass spectrometryRNA interferenceWestern blottingimmunofluorescence microscopyelectrophysiology
Output against the department
Publications135bottom 48% of dept.530th of 1,033
this lab
most publishedleast published
Citations2.4kbottom 17% of dept.854th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.