Johns Hopkins University · BiologyEgeblad Lab
Mikala Egeblad · Baltimore, Maryland
Research Focus
Dr. Mikala Egeblad's lab at Johns Hopkins University studies how chronic psychological stress influences cancer metastasis. The research focuses on understanding the biological pathways between the brain and the body that contribute to the spread of cancer, particularly through the activation of stress-related hormones and immune responses. By using mouse models, the lab aims to uncover mechanisms that could eventually lead to better prevention and treatment strategies for metastatic cancers.
metastasischronic stressneutrophil extracellular trapsimmune responsesympathetic nervous systemHPA axiscancer recurrencepancreatic cancerbreast cancer
Research Aims
3AIM 01Investigate how glucocorticoids trigger NET formation and how NETs promote metastasis.
AIM 02Determine the influence of the sympathetic nervous system on immune checkpoint blockade responses.
AIM 03Study the changes in electrophysiological properties of stress-regulating neurons in response to metastasizing cancer.
Skills the Lab Values
molecular biology techniquesmouse modelsstress protocolsimmunohistochemistryelectrophysiologywestern blottingmicroscopyadrenergic receptor manipulationdata analysis using R or Python
Output against the department
Publications237top 26% of dept.265th of 1,033
this lab
most publishedleast published
Citations38ktop 7% of dept.76th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.