University of Utah · BiologyT Cell Interaction Lab
Brian D Evavold · Salt Lake City, Utah
Research Focus
Dr. Brian D. Evavold's lab focuses on understanding how T cell receptors (TCRs) recognize antigens and how this interaction influences immune responses, particularly in autoimmune diseases like multiple sclerosis. By studying the physical properties of TCRs, such as bond lifetime and force, the lab aims to reveal critical information about T cell behavior and function. This research has the potential to lead to new therapies for autoimmune conditions by improving our understanding of how T cells can be regulated during immune responses.
T cell receptorautoimmune diseasesbond lifetimeforce measurementregulatory T cells
Research Aims
3AIM 01Investigate how bond lifetime and force between TCR and pMHC affect T cell phenotype.
AIM 02Analyze the differences in antigen recognition between functional and defective regulatory T cells.
AIM 03Explore the potential of TCR engineering to enhance understanding of affinity and bond lifetime effects on T cell responses.
Skills the Lab Values
cell culturemouse modelsflow cytometrybiophysical assaysprotein engineeringimmunological assays
Output against the department
Publications208top 31% of dept.324th of 1,033
this lab
most publishedleast published
Citations9.8ktop 39% of dept.400th of 1,033
this lab
most citedleast cited
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