Stanford University · Microbiology & ImmunologyCarette Virology Lab
Jan E Carette · Stanford, California
Research Focus
Dr. Jan E. Carette's lab focuses on understanding how certain enteroviruses, which can cause severe neurological problems in children, infect human cells. They use advanced human cell models to study these viruses' interactions with host cells, aiming to uncover new ways to prevent or treat diseases caused by these viruses. The lab combines cutting-edge genetic techniques with stem cell biology to explore the molecular mechanisms of viral entry and pathogenesis.
enterovirusesneurotropismcell tropismviral entryhuman organoidsCRISPR screeningneuropathogenesisacute flaccid myelitishost factorsneuro-muscular junctions
Research Aims
4AIM 01Investigate the role of host factors in enterovirus infection using human organoid models.
AIM 02Identify new molecular mechanisms of viral entry of enteroviruses into human cells.
AIM 03Understand the interactions between enteroviruses and their receptors in human neural tissues.
AIM 04Develop therapeutic strategies targeting host factors involved in viral pathogenesis.
Skills the Lab Values
3D cell cultureCRISPR-Cas9genome-scale screeningorgan transplantation techniquesimmunofluorescence microscopyviral infection assaysmolecular cloningcell line developmentprimary cell culturelive-cell imaging
Output against the department
Publications193top 33% of dept.161st of 486
this lab
most publishedleast published
Citations14ktop 27% of dept.131st of 486
this lab
most citedleast cited
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