Indiana University-Purdue University-Indianapolis · BiochemistryWeiss Insulin Lab
Michael Aaron Weiss · Indianapolis, Indiana
Research Focus
Dr. Michael Aaron Weiss's lab focuses on creating and studying new types of insulin that can help treat Type 1 diabetes more effectively and safely. They are particularly interested in how changes in the structure of insulin can improve its function and reduce side effects, such as low blood sugar. The lab uses advanced techniques like cryo-electron microscopy to analyze insulin's behavior and develop analogs that respond to glucose levels in the body, potentially transforming diabetes management.
insulin analogsType 1 diabetesstructural biologyglucose-responsive insulinbiophysicsmolecular designcryogenic electron microscopypharmacology
Research Aims
3AIM 01Investigate the structural discrepancies in insulin fibrils using advanced imaging techniques.
AIM 02Explore the impact of the C-domain length on insulin's ability to resist fibrillation and bind to receptors.
AIM 03Develop a novel class of glucose-responsive insulin analogs with safety features to prevent hypoglycemia.
Skills the Lab Values
cryogenic electron microscopyprotein synthesisNMR spectroscopyprotein engineeringstructural analysisin vivo animal modelschemical modification of proteinsmolecular modeling
Output against the department
Publications404top 12% of dept.50th of 402
this lab
most publishedleast published
Citations14ktop 34% of dept.137th of 402
this lab
most citedleast cited
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