Dartmouth College · Microbiology & ImmunologyBrain Immunity and Neuroinflammation Lab
Pamela Rosato · Hanover, New Hampshire
Research Focus
Dr. Pamela Rosato's lab at Dartmouth College focuses on studying the role of brain resident T cells in Alzheimer's Disease. The lab investigates how these immune cells, particularly a type called CD8+ tissue resident memory T cells, influence disease progression and cognitive decline. By combining mouse models with human tissue analysis, the lab aims to uncover novel therapeutic targets and improve our understanding of neuroinflammation in Alzheimer's and potentially other neurological disorders.
Alzheimer's DiseaseT cellsneuroinflammationimmune activationmouse modelstherapeutic targetscognitionmemory T cells
Research Aims
3AIM 01Investigate how CD8+ tissue resident memory T cells activate other immune cells in the brain during Alzheimer's disease.
AIM 02Determine the impact of T cell activation on cognitive decline in mouse models of Alzheimer's disease.
AIM 03Examine the migration and clonality of brain resident T cells in Alzheimer's disease in both mouse and human brains.
Skills the Lab Values
immunohistochemistryflow cytometrymouse modelssingle-cell sequencingcell cultureT cell activation assaysclonal expansion analysisimmunological techniquesdata analysis
Output against the department
Publications71bottom 21% of dept.381st of 486
this lab
most publishedleast published
Citations3.6kbottom 27% of dept.356th of 486
this lab
most citedleast cited
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