Wayne State University · PharmacologySynergistic Bacteriophage Research Lab
Michael Joseph Rybak · Detroit, Michigan
Research Focus
Dr. Michael Rybak's lab focuses on innovative strategies to combat difficult bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). The research emphasizes the synergy between bacteriophages and antibiotics, aiming to enhance treatment efficacy and prevent resistance. By combining these therapies, the lab seeks to improve patient outcomes and translate findings into clinical applications.
bacteriophagesantibiotic resistanceMRSAsynergyphage-antibiotic combinations
Research Aims
5AIM 01Investigate the synergistic mechanisms of phage-antibiotic combinations against MRSA.
AIM 02Optimize treatment regimens to improve efficacy and prevent resistance.
AIM 03Translate laboratory findings to preclinical models of infective endocarditis.
AIM 04Assess the impact of treatment strategies on bacterial killing rates.
AIM 05Develop protocols for advancing successful treatments to human clinical trials.
Skills the Lab Values
cell cultureantibiotic susceptibility testingflow cytometryin vitro experimentationpreclinical animal models
Output against the department
Publications562top 9% of dept.42nd of 462
this lab
most publishedleast published
Citations37ktop 7% of dept.31st of 462
this lab
most citedleast cited
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