Rutgers University-New Brunswick · NeuroscienceThe Cochlear Epigenetics Lab
Kelvin Y. Kwan · New Brunswick, New Jersey
Research Focus
Kelvin Y. Kwan's lab at Rutgers University focuses on investigating the epigenetic factors that contribute to hearing loss, particularly through the study of the CHD4 protein in the cochlea. The team explores how alterations in CHD4 affect hair cell identity and function, with the goal of uncovering mechanisms for hair cell maintenance and potential regeneration. This research could lead to novel therapies for treating various forms of hearing impairment.
epigeneticscochleahearing lossCHD4hair cell regenerationchromatin remodelingWnt signalingDNA methylationneurodevelopmental disorders
Research Aims
3AIM 01Investigate how CHD4 ablation affects gene regulatory networks in hair cells.
AIM 02Examine the impact of Wnt signaling on chromatin accessibility in supporting cells.
AIM 03Explore the relationship between CHD4 loss and DNA methylation changes at hair cell gene promoters.
Skills the Lab Values
PCRDNA methylation profilingchromatin accessibility assayssingle-cell RNA sequencingcell cultureanimal modelsmolecular cloningflow cytometryWestern blot
Output against the department
Publications76bottom 22% of dept.526th of 671
this lab
most publishedleast published
Citations6.2kbottom 43% of dept.385th of 671
this lab
most citedleast cited
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