University of Pittsburgh-Pittsburgh Campus · BiologyEbrahimkhani Lab
Mo Reza Ebrahimkhani · Pittsburgh, Pennsylvania
Research Focus
Dr. Mo Reza Ebrahimkhani's lab focuses on creating advanced in vitro human organoids that mimic the structure and function of real human tissues. The research aims to improve the engineering of these organoids by using synthetic and systems biology methods, which can enhance their development and robustness. By utilizing genetically engineered clones and computational models, the lab seeks to address challenges in organoid maturity and diversity, ultimately contributing to advancements in regenerative medicine and reducing reliance on animal models.
organoidssynthetic biologysystems biologystem cell engineeringregenerative medicinetissue developmenthuman biologycomputational modeling
Research Aims
5AIM 01Establish a clonally resolved engineering approach to build reliable human organoids.
AIM 02Develop a computational platform for designing organoid variants with specific hepatic functions.
AIM 03Enhance the reproducibility of stem cell-derived tissues ex vivo.
AIM 04Utilize genetic technologies to study and influence cellular decisions in organoid development.
AIM 05Create a framework for rational engineering of multicellular systems for regenerative applications.
Skills the Lab Values
cell culturegenetic engineeringorganoid formationcomputational modelinggene expression analysisbiochemical assaysdata analysistissue engineeringCRISPR
Output against the department
Publications86bottom 28% of dept.744th of 1,033
this lab
most publishedleast published
Citations3.7kbottom 29% of dept.735th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.