Rutgers University-New Brunswick · BiologyGlymphatic Health Research Unit
Max Tischfield · New Brunswick, New Jersey
Research Focus
Dr. Max Tischfield's lab at Rutgers University studies how the brain clears out harmful waste and proteins that accumulate due to aging and diseases like Alzheimer's. They focus on understanding the glymphatic system, which uses cerebrospinal fluid (CSF) to flush out toxins. By exploring a specific ion channel called Piezo1, the lab aims to uncover new therapeutic strategies to improve brain health and cognitive function, especially in older adults.
glymphatic systembrain healthcerebrospinal fluidAlzheimer's diseasemechanosensitive ion channelPiezo1waste clearanceneurotoxinsaging
Research Aims
3AIM 01Investigate whether Yoda1 enhances brain-CSF perfusion by acting on brain border macrophages
AIM 02Test if Piezo1 is required in brain border macrophages for maintaining CSF hydrodynamics
AIM 03Examine the effect of Piezo1 on amyloid pathology in Alzheimer's disease models
Skills the Lab Values
mouse geneticshigh-resolution multi-photon imagingcomputational modelingpharmacological testinggene manipulationimmunohistochemistrycell culturemicroscopyCRISPR
Output against the department
Publications48bottom 11% of dept.919th of 1,033
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.786th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.