SLUSaint Louis University · Biochemistry
Genomic Integrity and Repair Unit
Edwin Antony · Saint Louis, Missouri
Research Focus
Dr. Edwin Antony's research lab at Saint Louis University focuses on understanding the role of proteins that interact with DNA, specifically how they regulate the processes that maintain genomic integrity. The lab investigates the function of Replication Protein A (RPA) in DNA metabolism and how it collaborates with other proteins to repair DNA and prevent diseases such as cancer. They utilize advanced techniques to explore the mechanisms of DNA repair pathways, contributing to the development of potential cancer therapies.
DNA metabolismgenomic stabilityDNA repairReplication Protein A (RPA)homologous recombinationcancer biologybiophysical techniquesprotein interactionssingle-stranded DNA
Research Aims
5AIM 01Investigate how RPA interacts with DNA processing enzymes.
AIM 02Determine mechanisms that allow DNA repair enzymes to remove RPA from ssDNA.
AIM 03Explore the structural dynamics of RPA during DNA metabolic processes.
AIM 04Identify the role of post-translational modifications of RPA in its function.
AIM 05Decipher the coordination of proteins in the formation of Rad51 nucleoprotein filaments.
Skills the Lab Values
Molecular cloningProtein purificationFluorescence microscopySingle-molecule FRETBiochemical assaysCell cultureDNA manipulation techniquesWestern blottingMass spectrometry
Output against the department
Publications115bottom 30% of dept.281st of 402
this lab
most publishedleast published
Citations2.3kbottom 9% of dept.367th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.