Northeastern University · EngineeringVascular Adaptation Laboratory
Guohao Dai · Boston, Massachusetts
Research Focus
Dr. Guohao Dai's lab at Northeastern University focuses on understanding how certain proteins, known as Sox13 and Sox17, influence the behavior of blood vessel cells. By studying the differences between arterial and venous cells, the lab aims to improve how blood vessels adapt to changes in blood flow. Their work could lead to better treatments for vascular diseases and improvements in tissue-engineered grafts used in medicine.
vascular biologyendothelial cellssmooth muscle cellsvascular diseasestissue engineeringgene expressionSox17Sox13blood vessel adaptationcell communication
Research Aims
5AIM 01Investigate the role of Sox13 and Sox17 in regulating blood vessel cell types.
AIM 02Explore the crosstalk between endothelial cells and smooth muscle cells.
AIM 03Understand how changes in these proteins affect blood vessel structure and function.
AIM 04Develop in vitro models to study vascular remodeling.
AIM 05Identify potential clinical applications for vascular grafts.
Skills the Lab Values
cell cultureanimal modelingco-culture techniquesgene expression analysismolecular profilingbioengineeringtissue engineeringdata analysisimmunofluorescencemicroscopy
Output against the department
Publications140bottom 33% of dept.186th of 278
this lab
most publishedleast published
Citations7.6ktop 48% of dept.134th of 278
this lab
most citedleast cited
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