Case Western Reserve University · GeneticsAndrogen Receptor Therapeutics Lab
Berkley E Gryder · Cleveland, Ohio
Research Focus
Dr. Berkley E. Gryder's lab at Case Western Reserve University studies advanced prostate cancer, focusing on understanding how the androgen receptor (AR) can be targeted to suppress cancer growth. They are developing innovative small molecule therapies that can switch the function of the AR from promoting tumor growth to inhibiting it. By exploring the molecular and epigenetic mechanisms involved, the lab aims to improve treatment strategies for patients with resistant forms of prostate cancer.
androgen receptorprostate cancerepigeneticsgene regulationdrug development
Research Aims
5AIM 01Map the epigenetic mechanisms in metastatic castration-resistant prostate cancer.
AIM 02Develop small molecules that can switch androgen receptor function.
AIM 03Analyze the role of co-regulators in AR-super clusters in cancer.
AIM 04Investigate the effects of AR inverse agonists on tumor-driving genes.
AIM 05Create functional 3D epigenetic maps of prostate cancer regulatory networks.
Skills the Lab Values
molecular cloningChIP-seqcell cultureWestern blottingcomputational biologysmall molecule synthesis3D epigenetic mappingtumor modelinggenomic analysis
Output against the department
Publications288top 28% of dept.73rd of 259
this lab
most publishedleast published
Citations3.9kbottom 20% of dept.207th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.