University of California-San Francisco · NeuroscienceSleep Biology and Neurodegeneration Lab
Ying-Hui Fu · San Francisco, California
Research Focus
Dr. Ying-Hui Fu's lab at UCSF focuses on understanding how sleep quality and efficiency are regulated by the brain and nervous system. The lab studies individuals with genetic traits for natural short sleep, identifying specific genes that may lead to better sleep efficiency without negative health impacts. Using mouse models, the research explores the protective effects of quality sleep against neurodegenerative diseases, aiming to uncover mechanisms that could promote healthier aging and cognitive function.
sleep regulationneurodegenerative diseasesgenetic traitsmouse modelscognitive functionAlzheimer's diseasemolecular pathwayshealth and longevityneuroscience
Research Aims
5AIM 01Investigate the mechanisms that regulate sleep efficiency in the brain.
AIM 02Identify genetic factors associated with natural short sleep traits.
AIM 03Explore the relationship between sleep quality and neurodegenerative diseases.
AIM 04Understand the protective effects of quality sleep on cognitive health.
AIM 05Develop strategies to promote health longevity through better sleep.
Skills the Lab Values
mouse modelsgene mappingsleep study techniquesbehavioral testingmolecular biology techniquesPCRimmunohistochemistrydata analysisbioinformatics
Output against the department
Publications140bottom 49% of dept.343rd of 671
this lab
most publishedleast published
Citations18ktop 23% of dept.152nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.