University of Chicago · GeneticsEpithelial Dynamics and Tissue Assembly Lab
Sally Horne-Badovinac · Chicago, Illinois
Research Focus
Dr. Sally Horne-Badovinac's lab at the University of Chicago focuses on how groups of epithelial cells migrate together and assemble their surrounding environments during tissue development and repair. Using fruit flies as a model organism, the lab investigates the local interactions between cells that promote coordinated movement and how these movements help to form structures like the basement membrane, which supports organs. This research is important for understanding processes such as wound healing, organ development, and diseases related to tissue structure.
epithelial migrationbasement membrane assemblyDrosophilatissue morphogenesiscell-cell interactionscollective motilityorgan developmentrotational migrationextracellular matrixmechanical forces
Research Aims
5AIM 01Define the local cell-cell interactions that organize epithelial cells for collective migration.
AIM 02Explore how rotational migration affects basement membrane assembly.
AIM 03Determine the molecular mechanisms of planar signaling in cells.
AIM 04Investigate the role of mechanical forces in shaping basement membranes.
AIM 05Understand how tissue-level order emerges from local interactions among cells.
Skills the Lab Values
cell culturemolecular biology techniquesgenetic manipulationimmunofluorescencelive-cell imagingmicroscopyprotein analysisdata analysis in biologyDrosophila geneticssignal transduction studies
Output against the department
Publications59bottom 12% of dept.227th of 259
this lab
most publishedleast published
Citations2.4kbottom 12% of dept.229th of 259
this lab
most citedleast cited
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