University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyThe Immune Nexus Lab
Lawrence P. Kane · Pittsburgh, Pennsylvania
Research Focus
The research lab led by Dr. Lawrence P. Kane at the University of Pittsburgh focuses on understanding how certain immune cells regulate the body's response to cancer. By studying proteins like Tim-3 and their interaction with other immune pathways, the lab aims to develop more effective immunotherapies for solid tumors. The ultimate goal is to enhance the immune system's ability to fight cancer by targeting specific immune cells and pathways.
immunotherapycheckpoint blockaderegulatory T cellsTim-3tumor microenvironmentPD-1cancer treatmentT cell responsemouse modelssolid tumors
Research Aims
3AIM 01Identify the mechanism behind fewer effector Tregs in tumors lacking Tim-3.
AIM 02Analyze how Treg Tim-3 influences the tumor microenvironment.
AIM 03Evaluate Tim-3's role in regulating responses to PD-1 blockade therapies.
Skills the Lab Values
cell cultureflow cytometrymouse modelsgene knockout techniquesimmunohistochemistrycytokine assaysWestern blottingPCRRNA sequencingdata analysis
Output against the department
Publications362top 11% of dept.53rd of 486
this lab
most publishedleast published
Citations8.8ktop 41% of dept.200th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.