UMCUniversity of Massachusetts Chan Medical School · Microbiology & Immunology
Uterine Physiology and Ion Channel Lab
Ronghua Zhuge · Worcester, Massachusetts
Research Focus
Dr. Ronghua Zhuge's lab at the University of Massachusetts Medical School focuses on understanding how ion channels in uterine smooth muscle cells affect uterine contractions, which are important for reproduction. The lab studies conditions like adenomyosis, a disease that impacts many women and can cause significant distress. By exploring the roles of specific calcium channels in these muscles, the research aims to uncover new treatment strategies for gynecological disorders.
ion channelsuterine contractionadenomyosiscalcium signalingreproductionfertilitysmooth muscle cellsembryo implantation
Research Aims
3AIM 01Investigate the roles of Cav1.2 and Cav1.3 in calcium signaling and uterine peristalsis.
AIM 02Determine how Cav1.2 down-regulation affects uterine peristalsis leading to adenomyosis.
AIM 03Translate findings from mouse models to human uterine smooth muscle cells to understand adenomyosis better.
Skills the Lab Values
cell culturemouse modelsRNA interferencegene knockout techniquescalcium imagingimmunofluorescenceWestern blotelectrophysiology
Output against the department
Publications43bottom 8% of dept.448th of 486
this lab
most publishedleast published
Citations1.8kbottom 11% of dept.431st of 486
this lab
most citedleast cited
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