Duquesne University · BiologyMalaria Modulators Lab
David J Lampe · Pittsburgh, Pennsylvania
Research Focus
David J Lampe's research lab at Duquesne University focuses on combating malaria by engineering bacteria that can live in mosquitoes and help prevent the transmission of malaria parasites. The lab is developing new bacterial strains that do not have antibiotic resistance traits, aiming to make them safe and effective for release into the environment. By studying how these bacteria interact with mosquito gut microbiota, the lab seeks to enhance the natural defenses against malaria while ensuring that the bacteria persist in the wild without disrupting local ecosystems.
malariaparatransgenesisbacterial geneticsvector controlmicrobiota interactionsAsaia bogorensistransmissioneffector proteinsmosquitopublic health
Research Aims
5AIM 01Engineer bacterial strains that can produce anti-Plasmodium effector proteins.
AIM 02Assess the stability and fitness of engineered strains in mosquito populations.
AIM 03Investigate interactions between engineered bacteria and native gut microbiota.
AIM 04Identify field-ready bacterial strains that can reduce malaria transmission.
AIM 05Evaluate the ecological impact of releasing genetically modified bacteria into natural populations.
Skills the Lab Values
bacterial strain engineeringin vivo experimentsmicrobial ecologymolecular biology techniquesantibiotic resistance analysisfield data collectionfitness assessment of strainsbacterial community assessmentgenetic modificationbioinformatics
Output against the department
Publications54bottom 13% of dept.897th of 1,033
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.730th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.