University of Michigan-Ann Arbor · BiochemistryLaboratory of Bacterial Pathogenesis and Epigenetics
Raymond C Trievel · Ann Arbor, Michigan
Research Focus
Professor Raymond Trievel's lab at the University of Michigan studies how the bacteria Legionella pneumophila causes Legionnaires Disease, a severe form of pneumonia. The lab focuses on understanding specific proteins called lysine methyltransferases that help the bacteria survive and multiply within host cells by modifying histones, proteins that control gene expression. By exploring these molecular mechanisms, the lab aims to discover new therapeutic strategies to combat this dangerous pathogen.
Legionella pneumophilalysine methyltransferaseshistone modificationmacrophage infectionchromatin biologybacterial pathogenesisepigeneticsdisease treatment
Research Aims
3AIM 01Define the molecular mechanism of H3K14 methylation by RomA and LegAS4.
AIM 02Elucidate the structural basis of nucleosome recognition.
AIM 03Determine the functions of LegAS4 in macrophage infection.
Skills the Lab Values
biochemistry techniquesstructure determinationprotein expressionprotein purificationin vitro assayscell culturemicroscopybioinformaticsmolecular cloning
Output against the department
Publications116bottom 31% of dept.277th of 402
this lab
most publishedleast published
Citations7.8kbottom 42% of dept.234th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.