University of Alabama at Birmingham · BiologyAging and Ceramide Signaling Research Lab
Liou Sun · Birmingham, Alabama
Research Focus
The lab led by Liou Sun at the University of Alabama at Birmingham focuses on understanding the role of ceramide signaling in aging and age-related diseases. By using mouse models, the lab investigates how growth hormone deficiency impacts longevity and healthspan. Their work aims to uncover potential therapeutic interventions that could improve health during aging and combat diseases associated with aging, like tauopathies.
agingceramidesgrowth hormonehealthspantauopathylipid profilesmice modelspharmacological interventionslongevity
Research Aims
5AIM 01Investigate the role of ceramides in aging and longevity in mice.
AIM 02Explore the effects of growth hormone deficiency on lifespan.
AIM 03Determine the impact of genetic and pharmacological interventions that reduce ceramide levels.
AIM 04Understand how ceramide signaling affects healthspan and cellular processes.
AIM 05Develop new potential therapies aimed at extending healthy aging.
Skills the Lab Values
mouse modelsmolecular biology techniqueslipid profilinggenetic manipulationpharmacological testingcell cultureWestern blotflow cytometrydata analysis using programming
Output against the department
Publications78bottom 23% of dept.796th of 1,033
this lab
most publishedleast published
Citations2.7kbottom 20% of dept.827th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.