Yale University · BiologyHematopoietic Development and Linker Histones Lab
Shangqin Guo · New Haven, Connecticut
Research Focus
Dr. Shangqin Guo's lab focuses on understanding how certain proteins, known as linker histones, can influence the development of blood cells from their precursor cells. The research investigates how manipulating these proteins could lead to better outcomes in diseases like cancer and blood disorders by promoting the production of immune cells. The lab uses a variety of genetic models and inhibitors to explore these mechanisms at a molecular level, aiming to create new therapeutic strategies for treating hematological diseases.
linker histoneshematopoietic stem cellslymphopoiesisgene expressionprotease inhibitors
Research Aims
3AIM 01Investigate how linker histone H1.0 affects the lineage potential of blood precursor cells.
AIM 02Determine the mechanisms by which linker histones restrict access to genetic material and influence cell fate.
AIM 03Test the effects of protease inhibitors on sustaining linker histone levels to enhance cell differentiation.
Skills the Lab Values
PCRmouse modelsgene knockout techniquesflow cytometrymolecular cloning
Output against the department
Publications66bottom 17% of dept.853rd of 1,033
this lab
most publishedleast published
Citations3.7kbottom 28% of dept.743rd of 1,033
this lab
most citedleast cited
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