University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyDeluca Lab
Neal A. Deluca · Pittsburgh, Pennsylvania
Research Focus
Dr. Neal A. Deluca's lab focuses on how the herpes simplex virus (HSV) interacts with host cells to regulate gene expression. Their research aims to uncover the mechanisms that govern viral and cellular transcription during HSV infections. By understanding these interactions, the lab seeks to develop strategies to inhibit HSV replication, which could lead to better treatments for related viral diseases.
Herpes Simplex Virusvirus-cell interactionsgene expressiontranscription regulationviral proteins
Research Aims
3AIM 01Investigate how the viral protein ICP4 interacts with the cellular genome to influence gene expression.
AIM 02Examine the structure of the HSV genome and how it affects viral transcription.
AIM 03Explore the role of the mediator complex in transcription activation of viral genes.
Skills the Lab Values
PCRcell cultureprotein-protein interactionsgenomic toolsproteomicsRNA analysistranscription assaysvirus genetics
Output against the department
Publications108bottom 39% of dept.294th of 486
this lab
most publishedleast published
Citations8.6ktop 42% of dept.204th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.