Washington University in St Louis · GeneticsAxon Degeneration Research Lab
Jeffrey D Milbrandt · Saint Louis, Missouri
Research Focus
Dr. Jeffrey D. Milbrandt's lab at Washington University focuses on understanding the mechanisms behind axon degeneration, a process crucial for conditions like ALS and peripheral neuropathy. The research investigates the enzyme SARM1, which plays a vital role in neuroinflammation and axon damage. By studying how cellular metabolism and inflammation contribute to nerve degeneration, the lab aims to develop new therapeutic strategies to protect nerve cells and improve motor function in affected individuals.
axon degenerationneuroinflammationSARM1amyotrophic lateral sclerosis (ALS)metabolic pathwaysmacrophage recruitmentlactate metabolismperipheral nervous systemtherapeuticsSchwann cells
Research Aims
5AIM 01Investigate the role of SARM1 in neuroinflammation and axonal damage.
AIM 02Characterize the involvement of macrophages in axon degeneration processes.
AIM 03Dissect the impact of lactate metabolism on motor neuron health.
AIM 04Identify novel therapeutic strategies for combating peripheral neuropathy.
AIM 05Examine the interaction between genetic variants and axonal health in ALS.
Skills the Lab Values
mouse modelscell cultureimmunohistochemistryWestern blotRNA sequencinggene knockout techniquesbiochemical assaysviral overexpression techniquesphenotyping of micedata analysis using Python
Output against the department
Publications382top 20% of dept.51st of 259
this lab
most publishedleast published
Citations45ktop 14% of dept.36th of 259
this lab
most citedleast cited
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