University of Illinois Chicago · ChemistryCholesterol Homeostasis and Therapeutics Lab
Stephanie M Cologna · Chicago, Illinois
Research Focus
Dr. Stephanie M Cologna's lab focuses on finding new treatments for Niemann-Pick disease type C1, a severe disorder that affects the body's ability to manage cholesterol and can lead to early death. The lab works on understanding how specific peptides can improve cholesterol storage issues associated with this disease. Through biochemical studies and innovative techniques, the team aims to uncover new therapeutic methods to combat this currently untreatable condition, potentially extending the lives of affected individuals.
Niemann-Pick diseasecholesteroltherapeuticspeptidesbiochemistry
Research Aims
5AIM 01Develop new therapeutic peptides for Niemann-Pick disease type C1.
AIM 02Investigate the mechanisms by which peptides affect cholesterol storage.
AIM 03Perform lifespan studies to evaluate the effectiveness of peptide treatments.
AIM 04Understand protein and lipid responses to treatment in cell models.
AIM 05Utilize biochemical techniques to identify biomarkers of disease progression.
Skills the Lab Values
mass spectrometrycell culturebiomarker analysisdrug metabolism studiesmolecular biology techniques
Output against the department
Publications141bottom 34% of dept.142nd of 216
this lab
most publishedleast published
Citations1.9kbottom 15% of dept.184th of 216
this lab
most citedleast cited
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