Columbia University in the City of New York · BiologyAlzheimer's Pathogenesis and Viral Interactions Lab
Tal Nuriel · New York, New York
Research Focus
Dr. Tal Nuriel's lab at Columbia University focuses on understanding how long-term infections with herpes simplex virus (HSV-1) may contribute to the development of Alzheimer's disease, particularly in individuals with a genetic predisposition (APOE4 allele). The research aims to reveal the complex interactions between viral infection and brain function, which may lead to new treatments for preventing or slowing Alzheimer's disease in at-risk populations.
Alzheimer's diseaseherpes simplex virusAPOE4neurodegenerationviral infectionantiviral therapymemorycognitive declinepathogenesisgenetics
Research Aims
5AIM 01Investigate the impact of long-term latent HSV-1 infection on brain function and Alzheimer's disease development.
AIM 02Evaluate the role of the APOE4 allele in enhancing AD risk associated with HSV-1 infection.
AIM 03Test the efficacy of a new brain-penetrant antiviral medication in blocking effects of HSV-1 infection.
AIM 04Assess cognitive and pathological changes in experimental models over time post HSV-1 infection.
AIM 05Explore the interactions between neuronal health and viral infection in the context of Alzheimer’s disease.
Skills the Lab Values
mouse modelsin vitro cell culturebehavioral assaysimmunohistochemistryPCRRNA extractionantiviral drug testingdata analysis in bioinformaticsmemory assessment techniquesneurobiology methods
Output against the department
Publications53bottom 13% of dept.899th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.836th of 1,033
this lab
most citedleast cited
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