Baylor University · BiologyCellular Plasticity and Transition Unit
Joseph H. Taube · Waco, Texas
Research Focus
Dr. Joseph H. Taube's lab studies how cells transition between different states, particularly from epithelial to mesenchymal and back, which is important for processes like development, healing, and cancer. His research focuses on a protein called CTCF that helps organize DNA in the cell nucleus and influences these cellular changes. By investigating the effects of CTCF on gene expression and chromatin structure, the lab aims to uncover fundamental mechanisms of cellular plasticity that could inform treatments for diseases where these processes go awry.
epithelial-mesenchymal transitionCTCFchromatin loopingcellular plasticitygene expressionTGF-beta signalingcell migrationepigeneticsdisease modelingreversible EMT
Research Aims
5AIM 01Map chromatin loops and TADs during reversible epithelial-mesenchymal transition (EMT).
AIM 02Determine the impact of CTCF expression on partial EMT phenotypes.
AIM 03Evaluate the role of specific CTCF binding sites in chromatin looping and gene regulation.
AIM 04Investigate the relationship between cadherin expression and cell migration in hybrid EMT states.
AIM 05Elucidate mechanisms of chromatin organization influenced by CTCF in disease contexts.
Skills the Lab Values
ChIP-seqHiC-seq3C-qPCRChIP-qPCRcell culturegene expression analysiscell migration assayscomputational biologydata analysisepigenetic profiling
Output against the department
Publications94bottom 32% of dept.698th of 1,033
this lab
most publishedleast published
Citations2.8kbottom 21% of dept.817th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.