University of California-Los Angeles · PhysiologyGwack Lab
Yousang Gwack · Los Angeles, California
Research Focus
Dr. Yousang Gwack's lab at UCLA explores how genetic factors influence the immune system, particularly focusing on T cells and their response to autoimmune diseases. By examining mitochondrial function and integrity, the lab seeks to uncover the mechanisms that make some T cells more prone to attacking the body, which can lead to diseases such as arthritis and diabetes. Their work combines advanced genetic screening in mice with sophisticated imaging techniques to better understand these processes and push towards new treatments.
autoimmunityT cellsmitochondrial functiongenetic screeningreactive oxygen speciesTh1 cellsimmune responseprotein regulationhistone modification
Research Aims
3AIM 01Investigate the genetic factors that regulate mitochondrial cristae morphology in T cells.
AIM 02Examine the effects of excessive mitochondrial reactive oxygen species on T cell functions.
AIM 03Analyze the role of mitochondrial integrity in autoimmune responses using experimental models.
Skills the Lab Values
genetic manipulationmouse modelscell cultureflow cytometryreal-time PCRhigh-resolution imagingproteomicsRNA isolationimmunofluorescenceWestern blotting
Output against the department
Publications116bottom 34% of dept.187th of 286
this lab
most publishedleast published
Citations10ktop 30% of dept.87th of 286
this lab
most citedleast cited
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