Icahn School of Medicine at Mount Sinai · PharmacologyThe Hormone Health Lab
Mone Zaidi · New York, New York
Research Focus
Dr. Mone Zaidi's lab focuses on exploring the role of pituitary hormones, particularly follicle-stimulating hormone (FSH), in age-related diseases like osteoporosis, obesity, and Alzheimer's disease. They aim to develop therapeutic antibodies that can block FSH to prevent cognitive decline, bone loss, and obesity. The research combines insights from pharmacology, neuroscience, and bone biology to understand how these hormones affect health in older adults and to push new treatments into human clinical trials.
FSHAlzheimer's Diseaseosteoporosisobesityaging hormonestherapeutic antibodiessex differencesbone healthneurodegenerationmetabolic health
Research Aims
4AIM 01Identify the impact of FSH blockade on osteoporosis in aging mice.
AIM 02Explore the genetic deletion of FSH receptors in specific cell types and its consequences on metabolism.
AIM 03Investigate the role of LH receptor agonism on body fat reduction.
AIM 04Examine epidemiological relationships between FSH levels and cognitive decline in older adults.
Skills the Lab Values
antibody developmentmouse modelsgene knockout techniquescell culturepharmacokinetics testingbiostatisticsCRISPRWestern blotflow cytometrydata analysis using bioinformatics
Output against the department
Publications561top 9% of dept.43rd of 462
this lab
most publishedleast published
Citations21ktop 16% of dept.75th of 462
this lab
most citedleast cited
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