Carnegie Mellon University · Biomedical EngineeringCook Lab
Keith E Cook · Pittsburgh, Pennsylvania
Research Focus
Professor Keith E Cook's lab at Carnegie-Mellon University focuses on innovative ways to improve patient care during extracorporeal membrane oxygenation (ECMO) for those suffering from severe lung diseases. The research aims to develop advanced biomaterials that can help prevent excessive bleeding and blood clots in ECMO circuits, ultimately improving survival rates and easing patient treatment outside intensive care settings.
ECMObiomaterialsanticoagulationFactor XIIapolycarboxybetainechronic lung diseaseacute respiratory distress syndromethrombotic complicationsbleeding complications
Research Aims
5AIM 01Develop biomaterial coatings that minimize protein adsorption and platelet binding.
AIM 02Test the effectiveness of combined polycarboxybetaine and FXIIa inhibitor in preventing blood clots in vivo.
AIM 03Evaluate the safety and efficacy of new anticoagulation strategies during ECMO treatment.
AIM 04Simplify anticoagulation dosing regimens for clinical applications of ECMO.
AIM 05Investigate the potential for long-term ECMO support outside of intensive care.
Skills the Lab Values
biomaterial surface coatingin vitro testingin vivo experimentsanimal modelsdrug formulationblood coagulation assaysdata analysisclinical trial designemergency medicine applications
Output against the department
Publications170bottom 38% of dept.367th of 595
this lab
most publishedleast published
Citations2.2kbottom 16% of dept.499th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.