University of Pennsylvania · PhysiologyAxonal Transport and Organelle Dynamics Unit
Erika L Holzbaur · Philadelphia, Pennsylvania
Research Focus
Dr. Erika L Holzbaur's lab at the University of Pennsylvania studies how organelles and proteins are transported within neurons. This transport is crucial for neuron health and function since defects in this process can lead to neurodegenerative diseases like ALS. The lab uses advanced imaging techniques to understand the mechanisms involved, especially the roles of different molecular motors and the cytoskeleton in moving organelles like mitochondria and synaptic vesicles along axons.
axonal transportorganelle dynamicsmolecular motorscytoskeletonneurodegenerationlive cell imagingmitochondriasynaptic vesiclesneuron functiontargeted therapies
Research Aims
5AIM 01Investigate the mechanisms regulating organelle transport in neurons.
AIM 02Understand how axonal transport contributes to neuron health and function.
AIM 03Study the remodeling of organelles by molecular motors and cytoskeletal dynamics.
AIM 04Explore cargo-specific regulation of molecular motors during transport.
AIM 05Develop insights into therapeutic approaches for neurodegenerative diseases.
Skills the Lab Values
live cell imagingin vitro reconstitutionsingle molecule techniquesimmunofluorescencefluorescence microscopycell culturemolecular cloningprotein purificationbiochemical assaysdata analysis
Output against the department
Publications343top 12% of dept.34th of 286
this lab
most publishedleast published
Citations26ktop 9% of dept.27th of 286
this lab
most citedleast cited
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