Washington University in St Louis · Biomedical EngineeringNanofiber Vaccine Innovation Lab
Jai Rudra · Saint Louis, Missouri
Research Focus
Dr. Jai Rudra's lab focuses on developing innovative vaccines using self-assembling nanofibers that can help combat neurodegenerative diseases such as Alzheimer's and frontotemporal dementia. The lab's approach uses specially designed peptides that form non-toxic nanofibers, encouraging the body to generate immune responses without the harmful side effects often seen with traditional vaccines. By studying how these nanofibers interact with the immune system, the lab aims to create safer and more effective therapies for these critical health challenges affecting aging populations.
nanofibersneurodegenerationAlzheimer's diseasefrontotemporal dementiavaccinespeptide designimmune responseself-adjuvanting
Research Aims
3AIM 01Assess toxicity and seeding capacity of peptide nanofibers bearing Alzheimer’s and Tau epitopes.
AIM 02Characterize antibody responses to peptide nanofiber vaccines targeting Alzheimer’s and Tau proteins.
AIM 03Develop multi-epitope peptide nanofiber vaccines and test their efficacy in transgenic mouse models.
Skills the Lab Values
peptide synthesisnanofiber characterizationmouse modelsimmunology techniquesantibody assaystoxicity assessmentprotein engineeringflow cytometryvaccine developmentdata analysis
Output against the department
Publications79bottom 12% of dept.523rd of 595
this lab
most publishedleast published
Citations3.5kbottom 27% of dept.432nd of 595
this lab
most citedleast cited
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